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Howe GR, Benito E, Castelleto R, et al

Several targeted drugs have been further synthesized and developed, and currently under clinical trials

In recent decades, calcium channel blockers and modulators of mitochondrial dynamics, such as mitochondrial division inhibitor 1 (Mdivi-1) and the mitochondrial fusion promoter M1, have demonstrated cardioprotective and neuroprotective properties in various experimental models [129, 135, 136]